Maturitas. 2017 Mar;97:61-65.
doi: 10.1016/j.maturitas.2016.12.010. Epub 2017 Jan 10.

Author
Tuomikoski P¹, Savolainen-Peltonen H².

Author information
1. University of Helsinki, Helsinki, Finland. Electronic address: tuomikoski.pauliina@gmail.com.
2. University of Helsinki, Helsinki, Finland; Helsinki University Hospital, Department of Obstetrics and Gynecology, 00029 Helsinki, Finland.

Abstract
A vast majority of menopausal women suffer from vasomotor symptoms, such as hot flushes and night sweats, the mean duration of which may be up to 7-10 years. In addition to a decreased quality of life, vasomotor symptoms may have an impact on overall health. Vasomotor symptoms are associated with overactivity of the sympathetic nervous system, and sympathetic overdrive in turn is associated with metabolic syndrome, which is a known risk factor for cardiovascular disease. Menopausal hot flushes have a complex relationship to different features of the metabolic syndrome and not all data point towards an association between vasomotor symptoms and metabolic syndrome. Thus, it is still unclear whether vasomotor symptoms are an independent risk factor for metabolic syndrome. Research in this area is constantly evolving and we present here the most recent data on the possible association between menopausal vasomotor symptoms and the metabolic syndrome.

KEYWORDS:
Adipokines; Blood pressure; Hot flushes; Insulin resistance; Menopause; Metabolic syndrome; Obesity; Sympathetic overactivity